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Via the activation of TLR4/MAPK signaling in KCs ( In addition to HSCs, in an injured liver, hepatocytes and bile duct cells can also transform into fibroblasts via the process of epithelialmesenchymal transition (EMT), and excessive extracellular matrix (ECM) deposition by fibroblasts contributes to liver fibrosis

In total, 17 experimental arms were examined, comprising 1 placebo/control arm and 16 various dosage ranges of different GLP-1 receptor agonists/SGLT2 inhibitors arms

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